CATH Classification

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family L-lactate dehydrogenase A chain

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt P00338
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

P00338
LDHA_HUMAN
Homo sapiens
L-lactate dehydrogenase A chain

PDB Structure

PDB 4OKN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.
Kolappan, S., Shen, D.L., Mosi, R., Sun, J., McEachern, E.J., Vocadlo, D.J., Craig, L.
Acta Crystallogr.,Sect.D