CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.238 | Recoverin; domain 1 |
|
1.10.238.10 | EF-hand |
Domain Context
CATH Clusters
| Superfamily | EF-hand |
| Functional Family | calpain-3 isoform X1 |
Enzyme Information
| 3.4.22.54 |
Calpain-3.
based on mapping to UniProt P20807
Broad endopeptidase activity.
-!- Activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors gain access to the active site. -!- Substrates include the protein itself and connectin/titin. -!- Belongs to peptidase family C2.
|
UniProtKB Entries (1)
| P20807 |
CAN3_HUMAN
Homo sapiens
Calpain-3
|
PDB Structure
| PDB | 4OKH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of calpain-3 penta-EF-hand (PEF) domain - a homodimerized PEF family member with calcium bound at the fifth EF-hand.
Febs J.
|