CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.130 | Double-stranded beta-helix |
|
3.60.130.10 | Clavaminate synthase-like |
Domain Context
CATH Clusters
| Superfamily | Clavaminate synthase-like |
| Functional Family |
Enzyme Information
| 1.14.20.3 |
(5R)-carbapenem-3-carboxylate synthase.
based on mapping to UniProt Q9XB59
(3S,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O(2) = (5R)-carbapen- 2-em-3-carboxylate + succinate + CO(2) + H(2)O.
-!- The enzyme is involved in the biosynthesis of the carbapenem beta- lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. -!- It catalyzes a stereoinversion at C(5) and introduces a double bond between C-2 and C-3.
|
UniProtKB Entries (1)
| Q9XB59 |
CARC_PECCC
Pectobacterium carotovorum subsp. carotovorum
(5R)-carbapenem-3-carboxylate synthase
|
PDB Structure
| PDB | 4OJ8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics.
Science
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