CATH Domain 4oipA02
|2.170.120||RNA Polymerase Alpha Subunit; Chain A, domain 2|
|18.104.22.168||DNA-directed RNA polymerase, insert domain|
|Superfamily||DNA-directed RNA polymerase, insert domain|
|Functional Family||DNA-directed RNA polymerase subunit alpha|
DNA-directed RNA polymerase.
based on mapping to UniProt Q5SHR6
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 22.214.171.124 and EC 126.96.36.199.
UniProtKB Entries (1)
Thermus thermophilus HB8
DNA-directed RNA polymerase subunit omega
GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.