CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein phosphatase non-receptor type

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q06124
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

Q06124
PTN11_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 11

PDB Structure

PDB 4OHL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Yu, Z.H., Zhang, R.Y., Walls, C.D., Chen, L., Zhang, S., Wu, L., Liu, S., Zhang, Z.Y.
Biochemistry