CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Cathepsin D preproprotein

Enzyme Information

3.4.23.5
Cathepsin D.
based on mapping to UniProt P07339
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
-!- Occurs intracellularly, in lysosomes. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.23.

UniProtKB Entries (1)

P07339
CATD_HUMAN
Homo sapiens
Cathepsin D

PDB Structure

PDB 4OBZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based optimization of non-peptidic Cathepsin D inhibitors.
Gradler, U., Czodrowski, P., Tsaklakidis, C., Klein, M., Werkmann, D., Lindemann, S., Maskos, K., Leuthner, B.
Bioorg.Med.Chem.Lett.