CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

4.1.1.105
L-tryptophan decarboxylase.
based on mapping to UniProt A7B1V0
L-tryptophan = tryptamine + CO(2).
-!- The enzyme has been characterized from bacteria, plants, and fungi. -!- Unlike EC 4.1.1.28 this enzyme is specific for L-typtophan.

UniProtKB Entries (1)

A7B1V0
TRPDC_RUMGV
[Ruminococcus] gnavus ATCC 29149
Tryptophan decarboxylase

PDB Structure

PDB 4OBU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine.
Williams, B.B., Van Benschoten, A.H., Cimermancic, P., Donia, M.S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P.C., Fraser, J.S., Fischbach, M.A.
Cell Host Microbe