CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Mitogen-activated protein kinase kinase kinase kinase 4

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O95819
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O95819
M4K4_HUMAN
Homo sapiens
Mitogen-activated protein kinase kinase kinase kinase 4

PDB Structure

PDB 4OBP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization.
Crawford, T.D., Ndubaku, C.O., Chen, H., Boggs, J.W., Bravo, B.J., Delatorre, K., Giannetti, A.M., Gould, S.E., Harris, S.F., Magnuson, S.R., McNamara, E., Murray, L.J., Nonomiya, J., Sambrone, A., Schmidt, S., Smyczek, T., Stanley, M., Vitorino, P., Wang, L., West, K., Wu, P., Ye, W.
J.Med.Chem.