CATH Classification

Domain Context

CATH Clusters

Superfamily Nitrile hydratase, beta subunit
Functional Family Cobalt-containing nitrile hydratase subunit beta

Enzyme Information

4.2.1.84
Nitrile hydratase.
based on mapping to UniProt Q7SID3
An aliphatic amide = a nitrile + H(2)O.
-!- Acts on short-chain aliphatic nitriles, converting them into the corresponding acid amides. -!- Does not act on these amides or on aromatic nitriles (cf. EC 3.5.5.1).

UniProtKB Entries (1)

Q7SID2
NHAA_PSETH
Pseudonocardia thermophila
Cobalt-containing nitrile hydratase subunit alpha

PDB Structure

PDB 4OB1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The active site sulfenic acid ligand in nitrile hydratases can function as a nucleophile.
Martinez, S., Wu, R., Sanishvili, R., Liu, D., Holz, R.
J.Am.Chem.Soc.