CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.47.10
Functional Family Acetyl-CoA acetyltransferase

Enzyme Information

2.3.1.9
Acetyl-CoA C-acetyltransferase.
based on mapping to UniProt P14611
2 acetyl-CoA = CoA + acetoacetyl-CoA.
-!- The enzyme, found in both eukaryotes and prokaryotes, catalyzes the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. -!- The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. -!- In the second step the acyl group is transferred to an acetyl-CoA molecule. -!- Cf. EC 2.3.1.16.

UniProtKB Entries (1)

P14611
THIL_CUPNH
Cupriavidus necator H16
Acetyl-CoA acetyltransferase

PDB Structure

PDB 4O99
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure and biochemical characterization of PhaA from Ralstonia eutropha, a polyhydroxyalkanoate-producing bacterium.
Kim, E.J., Kim, K.J.
Biochem.Biophys.Res.Commun.