CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.80.10
Functional Family Protein-tyrosine kinase 2-beta isoform 1

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q05397
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q05397
FAK1_HUMAN
Homo sapiens
Focal adhesion kinase 1

PDB Structure

PDB 4NY0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
FAK dimerization controls its kinase-dependent functions at focal adhesions.
Brami-Cherrier, K., Gervasi, N., Arsenieva, D., Walkiewicz, K., Boutterin, M.C., Ortega, A., Leonard, P.G., Seantier, B., Gasmi, L., Bouceba, T., Kadare, G., Girault, J.A., Arold, S.T.
Embo J.