CATH Domain 4nwlA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.120

Domain Context

CATH Clusters

Superfamily	2.40.10.120
Functional Family

Enzyme Information

UniProtKB Entries (1)

A8DG50_9HEPC

Hepatitis C virus subtype 1a

Genome polyprotein

PDB Structure

PDB	4NWL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. Scola, P.M., Wang, A.X., Good, A.C., Sun, L.Q., Combrink, K.D., Campbell, J.A., Chen, J., Tu, Y., Sin, N., Venables, B.L., Sit, S.Y., Chen, Y., Cocuzza, A., Bilder, D.M., D'Andrea, S., Zheng, B., Hewawasam, P., Ding, M., Thuring, J., Li, J., Hernandez, D., Yu, F., Falk, P., Zhai, G., Sheaffer, A.K., Chen, C., Lee, M.S., Barry, D., Knipe, J.O., Li, W., Han, Y.H., Jenkins, S., Gesenberg, C., Gao, Q., Sinz, M.W., Santone, K.S., Zvyaga, T., Rajamani, R., Klei, H.E., Colonno, R.J., Grasela, D.M., Hughes, E., Chien, C., Adams, S., Levesque, P.C., Li, D., Zhu, J., Meanwell, N.A., McPhee, F. J.Med.Chem.