CATH Classification

Domain Context

CATH Clusters

Superfamily Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain
Functional Family Cytosolic 5-nucleotidase 3-like

Enzyme Information

3.1.3.5
5'-nucleotidase.
based on mapping to UniProt Q9W197
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
-!- Wide specificity for 5'-nucleotides.
3.1.3.91
7-methylguanosine nucleotidase.
based on mapping to UniProt Q9W197
(1) N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate. (2) CMP + H(2)O = cytidine + phosphate.
-!- The enzyme also has low activity with N(7)-methyl-GDP, producing N(7)-methyl-GMP. -!- Does not accept AMP or GMP, and has low activity with UMP.

UniProtKB Entries (1)

Q9W197
5NT3B_DROME
Drosophila melanogaster
7-methylguanosine phosphate-specific 5'-nucleotidase

PDB Structure

PDB 4NWI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of the Novel Cytosolic 5'-Nucleotidase IIIB Explain Its Preference for m7GMP
Monecke, T., Buschmann, J., Neumann, P., Wahle, E., Ficner, R.
Plos One