CATH Classification

Domain Context

CATH Clusters

Superfamily 6-pyruvoyl tetrahydropterin synthase/QueD
Functional Family 6-carboxy-5,6,7,8-tetrahydropterin synthase

Enzyme Information

4.1.2.50
6-carboxytetrahydropterin synthase.
based on mapping to UniProt P65870
7,8-dihydroneopterin 3'-triphosphate + H(2)O = 6-carboxy-5,6,7,8- tetrahydropterin + acetaldehyde + triphosphate.
-!- Isolated from the bacteria Bacillus subtilis and Escherichia coli. -!- The reaction is part of the biosynthesis pathway of queuosine. -!- The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8- tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8- tetrahydropterin.

UniProtKB Entries (1)

P65870
QUED_ECOLI
Escherichia coli K-12
6-carboxy-5,6,7,8-tetrahydropterin synthase

PDB Structure

PDB 4NTN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biochemical and Structural Studies of 6-Carboxy-5,6,7,8-tetrahydropterin Synthase Reveal the Molecular Basis of Catalytic Promiscuity within the Tunnel-fold Superfamily.
Miles, Z.D., Roberts, S.A., McCarty, R.M., Bandarian, V.
J.Biol.Chem.