CATH Classification

Domain Context

CATH Clusters

Superfamily Aconitase, domain 3
Functional Family

Enzyme Information

4.2.1.35
(R)-2-methylmalate dehydratase.
based on mapping to UniProt P81291
(R)-2-methylmalate = 2-methylmaleate + H(2)O.
4.2.1.31
Maleate hydratase.
based on mapping to UniProt P81291
(R)-malate = maleate + H(2)O.
4.2.1.33
3-isopropylmalate dehydratase.
based on mapping to UniProt P81291
(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.
-!- Forms part of the leucine-biosynthesis pathway. -!- Brings about the interconversion of the two isomers of isopropylmalate.

UniProtKB Entries (1)

P81291
LEUC_METJA
Methanocaldococcus jannaschii DSM 2661
Isopropylmalate/citramalate isomerase large subunit

PDB Structure

PDB 4NQY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural characterization and comparison of the large subunits of IPM isomerase and homoaconitase from Methanococcus jannaschii
Lee, E.H., Lee, K., Hwang, K.Y.
Acta Crystallogr.,Sect.D