CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.287 | Helix Hairpins |
|
1.10.287.160 | HR1 repeat |
Domain Context
CATH Clusters
| Superfamily | HR1 repeat |
| Functional Family | Putative serine/threonine-protein kinase N2 |
Enzyme Information
| 2.7.11.13 |
Protein kinase C.
based on mapping to UniProt Q16512
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (2)
| D0ZVG2 |
SSPH1_SALT1
Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S
E3 ubiquitin-protein ligase SspH1
|
| Q16512 |
PKN1_HUMAN
Homo sapiens
Serine/threonine-protein kinase N1
|
PDB Structure
| PDB | 4NKG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase.
Mol.Cell.Biol.
|