CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family Heat shock protein HSP 90-alpha

Enzyme Information

UniProtKB Entries (1)

P07900
HS90A_HUMAN
Homo sapiens
Heat shock protein HSP 90-alpha

PDB Structure

PDB 4NH7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Correlation between chemotype-dependent binding conformations of HSP90 alpha / beta and isoform selectivity-Implications for the structure-based design of HSP90 alpha / beta selective inhibitors for treating neurodegenerative diseases.
Ernst, J.T., Liu, M., Zuccola, H., Neubert, T., Beaumont, K., Turnbull, A., Kallel, A., Vought, B., Stamos, D.
Bioorg.Med.Chem.Lett.