CATH Classification

Domain Context

CATH Clusters

Superfamily paz domain
Functional Family Putative Endoribonuclease Dicer

Enzyme Information

3.1.26.3
Ribonuclease III.
based on mapping to UniProt Q9UPY3
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- An endoribonuclease that cleaves double-stranded RNA molecules. -!- The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site. -!- Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage. -!- RNase III is involved in both rRNA processing and mRNA processing and decay.

UniProtKB Entries (1)

Q9UPY3
DICER_HUMAN
Homo sapiens
Endoribonuclease Dicer

PDB Structure

PDB 4NH6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
Tian, Y., Simanshu, D.K., Ma, J.B., Park, J.E., Heo, I., Kim, V.N., Patel, D.J.
Mol.Cell