CATH Classification

Domain Context

CATH Clusters

Superfamily Calcium-transporting ATPase, cytoplasmic domain N
Functional Family Calcium-transporting ATPase

Enzyme Information

7.2.2.10
P-type Ca(2+) transporter.
based on mapping to UniProt P04191
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria. -!- The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolyzed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolyzed. -!- In muscle cells Ca(2+) is transported from the cytosol into the sarcoplasmic reticulum. -!- Formerly EC 3.6.1.38 and EC 3.6.3.8.

UniProtKB Entries (1)

P04191
AT2A1_RABIT
Oryctolagus cuniculus
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

PDB Structure

PDB 4NAB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
SERCA mutant E309Q binds two Ca(2+) ions but adopts a catalytically incompetent conformation.
Clausen, J.D., Bublitz, M., Arnou, B., Montigny, C., Jaxel, C., Moller, J.V., Nissen, P., Andersen, J.P., le Maire, M.
Embo J.