CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1460
Functional Family Legumain

Enzyme Information

3.4.22.34
Legumain.
based on mapping to UniProt Q99538
Hydrolysis of proteins and small molecule substrates at -Asn-|- Xaa- bonds.
-!- Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. -!- Not inhibited by compound E-64. -!- Belongs to peptidase family C13.

UniProtKB Entries (1)

Q15828
CYTM_HUMAN
Homo sapiens
Cystatin-M

PDB Structure

PDB 4N6O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and mechanism of an aspartimide-dependent Peptide ligase in human legumain.
Dall, E., Fegg, J.C., Briza, P., Brandstetter, H.
Angew.Chem.Int.Ed.Engl.