1 keywords

CATH Domain 4n4wA02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.1070 Rhopdopsin 7-helix transmembrane proteins
Homologous Superfamily 1.20.1070.10 Rhodopsin 7-helix transmembrane proteins

Domain Context

CATH Clusters

Superfamily Rhodopsin 7-helix transmembrane proteins
Functional Family Smoothened, frizzled class receptor

Enzyme Information

UniProtKB Entries (2)

Q99835
SMO_HUMAN
Homo sapiens
Smoothened homolog
Q0SXH8
Q0SXH8_SHIF8
Shigella flexneri 5 str. 8401
Cytochrome b(562)

PDB Structure

PDB 4N4W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Wang, C., Wu, H., Evron, T., Vardy, E., Han, G.W., Huang, X.P., Hufeisen, S.J., Mangano, T.J., Urban, D.J., Katritch, V., Cherezov, V., Caron, M.G., Roth, B.L., Stevens, R.C.
Nat Commun