CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.780 | Hydroxylamine Oxidoreductase; Chain A, domain 1 |
|
1.10.780.10 | Hydroxylamine Oxidoreductase; Chain A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Hydroxylamine Oxidoreductase; Chain A, domain 1 |
| Functional Family | Hydroxylamine oxidoreductase |
Enzyme Information
| 1.7.2.6 |
Hydroxylamine dehydrogenase.
based on mapping to UniProt Q50925
(1) Hydroxylamine + H(2)O + 4 ferricytochrome c = nitrite + 4 ferrocytochrome c + 5 H(+). (2) Hydroxylamine + 3 ferricytochrome c = nitric oxide + 3 ferrocytochrome c + 3 H(+).
-!- The enzymes from the nitrifying bacterium Nitrosomonas europaea and the methylotrophic bacterium Methylococcus capsulatus are hemoproteins with seven c-type hemes and one specialized P460-type heme per subunit. -!- The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate. -!- While nitrite is the main product, the enzyme from Nitrosomonas europaea can produce nitric oxide as well. -!- Formerly EC 1.7.3.4.
|
UniProtKB Entries (1)
| Q82V11 |
Q82V11_NITEU
Nitrosomonas europaea ATCC 19718
Uncharacterized protein
|
PDB Structure
| PDB | 4N4N |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis of Biological NO Generation by Octaheme Oxidoreductases.
J.Biol.Chem.
|