CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.12760
Functional Family Cap methyltransferase 1

Enzyme Information

2.1.1.57
Methyltransferase cap1.
based on mapping to UniProt Q8N1G2
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)- (purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)- methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)- [mRNA].
-!- This enzyme catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine. -!- This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. -!- The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine. -!- Formerly EC 2.1.1.58.

UniProtKB Entries (1)

Q8N1G2
CMTR1_HUMAN
Homo sapiens
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

PDB Structure

PDB 4N48
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
Smietanski, M., Werner, M., Purta, E., Kaminska, K.H., Stepinski, J., Darzynkiewicz, E., Nowotny, M., Bujnicki, J.M.
Nat Commun