CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P08492
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P08492
HN_PI3H4
Human parainfluenza 3 virus (strain NIH 47885)
Hemagglutinin-neuraminidase

PDB Structure

PDB 4MZE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Interaction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo.
Xu, R., Palmer, S.G., Porotto, M., Palermo, L.M., Niewiesk, S., Wilson, I.A., Moscona, A.
MBio