CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Enzyme Information

4.2.99.20
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase.
based on mapping to UniProt P37355
5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.
-!- Involved in the biosynthesis of vitamin K2 (menaquinone). -!- In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival. -!- It had previously been thought that the reactions carried out by this enzyme and EC 2.2.1.9 were carried out by a single enzyme but this has since been disproved. -!- Formerly EC 2.5.1.64 and EC 4.2.99.n1.

UniProtKB Entries (1)

P37355
MENH_ECOLI
Escherichia coli K-12
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

PDB Structure

PDB 4MYD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular Basis of the General Base Catalysis of an alpha/beta-Hydrolase Catalytic Triad
Sun, Y., Yin, S., Feng, Y., Li, J., Zhou, J., Liu, C., Zhu, G., Guo, Z.
J.Biol.Chem.