CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Protein-tyrosine kinase HTK98, variant

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P12931
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P12931
SRC_HUMAN
Homo sapiens
Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB 4MXX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity.
Levinson, N.M., Boxer, S.G.
Nat.Chem.Biol.