CATH Classification

Domain Context

CATH Clusters

Superfamily EF-hand
Functional Family Peptidylprolyl isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q9NWM8
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q9NWM8
FKB14_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP14

PDB Structure

PDB 4MSP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of human peptidyl-prolyl cis-trans isomerase FKBP22 containing two EF-hand motifs.
Boudko, S.P., Ishikawa, Y., Nix, J., Chapman, M.S., Bachinger, H.P.
Protein Sci.