CATH Classification

Domain Context

CATH Clusters

Superfamily Transthyretin/hydroxyisourate hydrolase domain
Functional Family Transthyretin

Enzyme Information

UniProtKB Entries (1)

P02766
TTHY_HUMAN
Homo sapiens
Transthyretin

PDB Structure

PDB 4MRB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis.
Mangione, P.P., Porcari, R., Gillmore, J.D., Pucci, P., Monti, M., Porcari, M., Giorgetti, S., Marchese, L., Raimondi, S., Serpell, L.C., Chen, W., Relini, A., Marcoux, J., Clatworthy, I.R., Taylor, G.W., Tennent, G.A., Robinson, C.V., Hawkins, P.N., Stoppini, M., Wood, S.P., Pepys, M.B., Bellotti, V.
Proc.Natl.Acad.Sci.USA