CATH Classification

Domain Context

CATH Clusters

Superfamily lpxc deacetylase, domain 2
Functional Family UDP-3-O-acyl-N-acetylglucosamine deacetylase

Enzyme Information

3.5.1.108
UDP-3-O-acyl-N-acetylglucosamine deacetylase.
based on mapping to UniProt P0A725
UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
-!- The enzyme catalyzes a committed step in the biosynthesis of lipid A. -!- Formerly EC 3.5.1.n1.

UniProtKB Entries (1)

P0A725
LPXC_ECOLI
Escherichia coli K-12
UDP-3-O-acyl-N-acetylglucosamine deacetylase

PDB Structure

PDB 4MQY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC.
Lee, C.J., Liang, X., Gopalaswamy, R., Najeeb, J., Ark, E.D., Toone, E.J., Zhou, P.
Acs Chem.Biol.