CATH Domain 4mq2B02

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

2.7.12.1

Dual-specificity kinase.

based on mapping to UniProt Q13627

ATP + a protein = ADP + a phosphoprotein.

-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

DYR1A_HUMAN

Homo sapiens

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB	4MQ2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Anderson, K., Chen, Y., Chen, Z., Dominique, R., Glenn, K., He, Y., Janson, C., Luk, K.C., Lukacs, C., Polonskaia, A., Qiao, Q., Railkar, A., Rossman, P., Sun, H., Xiang, Q., Vilenchik, M., Wovkulich, P., Zhang, X. Bioorg.Med.Chem.Lett.