CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Tryptase gamma 1

Enzyme Information

3.4.21.59
Tryptase.
based on mapping to UniProt Q15661
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

Q15661
TRYB1_HUMAN
Homo sapiens
Tryptase alpha/beta-1

PDB Structure

PDB 4MPU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Target-Directed Self-Assembly of Homodimeric Drugs Against beta-Tryptase.
Giardina, S.F., Werner, D.S., Pingle, M., Foreman, K.W., Bergstrom, D.E., Arnold, L.D., Barany, F.
Acs Med.Chem.Lett.