CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain
Functional Family [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

Enzyme Information

2.7.11.2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase.
based on mapping to UniProt Q15119
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.
-!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. -!- Phosphorylation inactivates EC 1.2.4.1. -!- Formerly EC 2.7.1.99.

UniProtKB Entries (1)

Q15119
PDK2_HUMAN
Homo sapiens
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

PDB Structure

PDB 4MPE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket.
Tso, S.C., Qi, X., Gui, W.J., Wu, C.Y., Chuang, J.L., Wernstedt-Asterholm, I., Morlock, L.K., Owens, K.R., Scherer, P.E., Williams, N.S., Tambar, U.K., Wynn, R.M., Chuang, D.T.
J.Biol.Chem.