CATH Domain 4moyA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.21	Purple Acid Phosphatase; chain A, domain 2
	3.60.21.10	Metallo-dependent phosphatases

Domain Context

CATH Clusters

Superfamily	3.60.21.10
Functional Family	Serine/threonine-protein phosphatase

Enzyme Information

3.1.3.16

Protein-serine/threonine phosphatase.

based on mapping to UniProt P62136

[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.

-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (2)

O55000	PP1RA_RAT Rattus norvegicus Serine/threonine-protein phosphatase 1 regulatory subunit 10
P62136	PP1A_HUMAN Homo sapiens Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

PDB Structure

PDB	4MOY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code. Choy, M.S., Hieke, M., Kumar, G.S., Lewis, G.R., Gonzalez-Dewhitt, K.R., Kessler, R.P., Stein, B.J., Hessenberger, M., Nairn, A.C., Peti, W., Page, R. Proc.Natl.Acad.Sci.USA