CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Functional Family DNA oxidative demethylase ALKBH2

Enzyme Information

1.14.11.33
DNA oxidative demethylase.
based on mapping to UniProt Q6NS38
DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2).
-!- Activity is slightly stimulated by ascorbate. -!- Catalyzes oxidative demethylation of the DNA base lesions N(1)- methyladenine, N(3)-methylcytosine, N(1)-methylguanine, and N(3)- methylthymine. -!- It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.

UniProtKB Entries (1)

Q6NS38
ALKB2_HUMAN
Homo sapiens
DNA oxidative demethylase ALKBH2

PDB Structure

PDB 4MG2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The complex structures of ALKBH2 mutants cross-linked to dsDNA reveal the conformational swing of β-hairpin
Chen, B., Gan, J., Yang, C.G.
Sci China Chem