CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase, RBP11-like subunit
Functional Family DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P0A7Z4
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P0A7Z4
RPOA_ECOLI
Escherichia coli K-12
DNA-directed RNA polymerase subunit alpha

PDB Structure

PDB 4MEX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Transcription inhibition by the depsipeptide antibiotic salinamide A.
Degen, D., Feng, Y., Zhang, Y., Ebright, K.Y., Ebright, Y.W., Gigliotti, M., Vahedian-Movahed, H., Mandal, S., Talaue, M., Connell, N., Arnold, E., Fenical, W., Ebright, R.H.
Elife