CATH Classification

Domain Context

CATH Clusters

Superfamily tRNA(m1g37)methyltransferase, domain 2
Functional Family tRNA (guanine-N(1)-)-methyltransferase

Enzyme Information

2.1.1.228
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt P43912
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

P43912
TRMD_HAEIN
Haemophilus influenzae Rd KW20
TRNA (guanine-N(1)-)-methyltransferase

PDB Structure

PDB 4MCC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
Hill, P.J., Abibi, A., Albert, R., Andrews, B., Gagnon, M.M., Gao, N., Grebe, T., Hajec, L.I., Huang, J., Livchak, S., Lahiri, S.D., McKinney, D.C., Thresher, J., Wang, H., Olivier, N., Buurman, E.T.
J.Med.Chem.