CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family (2Z,6E)-hedycaryol synthase

Enzyme Information

4.2.3.187
(2Z,6E)-hedycaryol synthase.
based on mapping to UniProt E4MYY0
(2E,6E)-farnesyl diphosphate + H(2)O = (2Z,6E)-hedycaryol + diphosphate.
-!- Isolated from the bacterium Kitasatospora setae. -!- The stereochemistry suggests the farnesyl diphosphate rearranges to nerolidyl diphosphate or an equivalent intermediate before cyclization. -!- See also EC 4.2.3.174.

UniProtKB Entries (1)

E4MYY0
HCS_KITSK
Kitasatospora setae KM-6054
(2Z,6E)-hedycaryol synthase

PDB Structure

PDB 4MC0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism.
Baer, P., Rabe, P., Citron, C.A., de Oliveira Mann, C.C., Kaufmann, N., Groll, M., Dickschat, J.S.
Chembiochem