CATH Classification

Domain Context

CATH Clusters

Superfamily ATP-grasp fold, A domain
Functional Family

Enzyme Information

6.3.4.18
5-(carboxyamino)imidazole ribonucleotide synthase.
based on mapping to UniProt Q5NGE8
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
-!- In Escherichia coli, this enzyme, along with EC 5.4.99.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates. -!- Carboxyphosphate is the putative acyl phosphate intermediate. -!- Involved in the late stages of purine biosynthesis.

UniProtKB Entries (1)

Q5NGE8
Q5NGE8_FRATT
Francisella tularensis subsp. tularensis SCHU S4
N5-carboxyaminoimidazole ribonucleotide synthase

PDB Structure

PDB 4MAM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of phosphoribosylaminoimidazole carboxylase ATPase subunit of Francisella tularensis subsp. tularensis SCHU S4 in complex with an ADP analog, AMP-CP
Tan, K., Zhou, M., Kwon, K., Anderson, W.F., Joachimiak, A.
To be Published