CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00374
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00374
DYR_HUMAN
Homo sapiens
Dihydrofolate reductase

PDB Structure

PDB 4M6J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Divergent evolution of protein conformational dynamics in dihydrofolate reductase.
Bhabha, G., Ekiert, D.C., Jennewein, M., Zmasek, C.M., Tuttle, L.M., Kroon, G., Dyson, H.J., Godzik, A., Wilson, I.A., Wright, P.E.
Nat.Struct.Mol.Biol.