CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.10 | Ribbon |
|
2.10.50 | Tumor Necrosis Factor Receptor, subunit A; domain 2 |
|
2.10.50.10 | Tumor Necrosis Factor Receptor, subunit A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Tumor Necrosis Factor Receptor, subunit A, domain 2 |
| Functional Family | Ephrin type-A receptor 5 |
Enzyme Information
| 2.7.10.1 |
Receptor protein-tyrosine kinase.
based on mapping to UniProt P54764
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| P52803 |
EFNA5_HUMAN
Homo sapiens
Ephrin-A5
|
PDB Structure
| PDB | 4M4R |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.
Proc.Natl.Acad.Sci.USA
|