CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt Q05769
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

Q05769
PGH2_MOUSE
Mus musculus
Prostaglandin G/H synthase 2

PDB Structure

PDB 4M11
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.
Xu, S., Hermanson, D.J., Banerjee, S., Ghebreselasie, K., Clayton, G.M., Garavito, R.M., Marnett, L.J.
J.Biol.Chem.