CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P08631
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08631
HCK_HUMAN
Homo sapiens
Tyrosine-protein kinase HCK

PDB Structure

PDB 4LUE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
Parker, L.J., Taruya, S., Tsuganezawa, K., Ogawa, N., Mikuni, J., Honda, K., Tomabechi, Y., Handa, N., Shirouzu, M., Yokoyama, S., Tanaka, A.
Acta Crystallogr.,Sect.D