CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.130 | Double-stranded beta-helix |
|
3.60.130.30 |
Domain Context
CATH Clusters
| Superfamily | 3.60.130.30 |
| Functional Family |
Enzyme Information
| 1.14.11.n2 |
Methylcytosine dioxygenase.
based on mapping to UniProt D2W6T1
DNA 5-methylcytosine + 2-oxoglutarate + O(2) = DNA 5-hydroxymethylcytosine + succinate + CO(2).
-!- Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). -!- Might initiate a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. -!- Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation.
|
UniProtKB Entries (1)
| D2W6T1 |
TET1_NAEGR
Naegleria gruberi
Tet-like dioxygenase 1
|
PDB Structure
| PDB | 4LT5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA.
Nature
|