CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.47.10
Functional Family

Enzyme Information

2.3.1.179
Beta-ketoacyl-[acyl-carrier-protein] synthase II.
based on mapping to UniProt O34340
(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier- protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].
-!- Involved in the dissociated (or type II) fatty acid biosynthesis system that occurs in plants and bacteria. -!- While the substrate specificity of this enzyme is very similar to that of EC 2.3.1.41, it differs in that palmitoleoyl-ACP is not a good substrate of EC 2.3.1.41 but is an excellent substrate of this enzyme. -!- The fatty-acid composition of Escherichia coli changes as a function of growth temperature, with the proportion of unsaturated fatty acids increasing with lower growth temperature. -!- Controls the temperature-dependent regulation of fatty-acid composition, with mutants lacking this acivity being deficient in the elongation of palmitoleate to cis-vaccenate at low temperatures.

UniProtKB Entries (1)

O34340
FABF_BACSU
Bacillus subtilis subsp. subtilis str. 168
3-oxoacyl-[acyl-carrier-protein] synthase 2

PDB Structure

PDB 4LS6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights into bacterial resistance to cerulenin.
Trajtenberg, F., Altabe, S., Larrieux, N., Ficarra, F., de Mendoza, D., Buschiazzo, A., Schujman, G.E.
Febs J.