CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.880 | Class I glutamine amidotransferase (GATase) domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.880 |
| Functional Family | Glutathione-independent glyoxalase HSP31 |
Enzyme Information
| 4.2.1.130 |
D-lactate dehydratase.
based on mapping to UniProt Q5AF03
(R)-lactate = methylglyoxal + H(2)O.
-!- The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. -!- The other known route for this conversion is the two-step GSH- dependent pathway catalyzed by EC 4.4.1.5 and EC 3.1.2.6.
|
UniProtKB Entries (1)
| Q5AF03 |
HSP31_CANAL
Candida albicans SC5314
Glyoxalase 3
|
PDB Structure
| PDB | 4LRU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A Glutathione-independent Glyoxalase of the DJ-1 Superfamily Plays an Important Role in Managing Metabolically Generated Methylglyoxal in Candida albicans.
J.Biol.Chem.
|