CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family Farnesyl pyrophosphate synthase

Enzyme Information

2.5.1.1
Dimethylallyltranstransferase.
based on mapping to UniProt P14324
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
-!- Will not accept larger prenyl diphosphates as efficient donors.
2.5.1.10
(2E,6E)-farnesyl diphosphate synthase.
based on mapping to UniProt P14324
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate.
-!- Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. -!- The enzyme will not accept larger prenyl diphosphates as efficient donors.

UniProtKB Entries (1)

P14324
FPPS_HUMAN
Homo sapiens
Farnesyl pyrophosphate synthase

PDB Structure

PDB 4LPG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.
De Schutter, J.W., Park, J., Leung, C.Y., Gormley, P., Lin, Y.S., Hu, Z., Berghuis, A.M., Poirier, J., Tsantrizos, Y.S.
J.Med.Chem.