CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family DNA gyrase subunit B

Enzyme Information

UniProtKB Entries (1)

Q8DQB5
Q8DQB5_STRR6
Streptococcus pneumoniae R6
DNA topoisomerase 4 subunit B

PDB Structure

PDB 4LP0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents.
Basarab, G.S., Manchester, J.I., Bist, S., Boriack-Sjodin, P.A., Dangel, B., Illingworth, R., Sherer, B.A., Sriram, S., Uria-Nickelsen, M., Eakin, A.E.
J.Med.Chem.