CATH Classification

Domain Context

CATH Clusters

Superfamily Glutamine synthetase/guanido kinase, catalytic domain
Functional Family Glutamine synthetase 2

Enzyme Information

6.3.1.2
Glutamine synthetase.
based on mapping to UniProt P12425
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.
-!- Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. -!- Several types have been described, differing in their oligomeric structures and cofactor requirements.

UniProtKB Entries (1)

P12425
GLN1A_BACSU
Bacillus subtilis subsp. subtilis str. 168
Glutamine synthetase

PDB Structure

PDB 4LNK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism.
Murray, D.S., Chinnam, N., Tonthat, N.K., Whitfill, T., Wray, L.V., Fisher, S.H., Schumacher, M.A.
J.Biol.Chem.