CATH Classification

Domain Context

CATH Clusters

Superfamily POLO box domain
Functional Family Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21
Polo kinase.
based on mapping to UniProt P53350
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P53350
PLK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase PLK1

PDB Structure

PDB 4LKL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1
Murugan, R.N., Ahn, M., Lee, W.C., Kim, H.Y., Song, J.H., Cheong, C., Hwang, E., Seo, J.H., Shin, S.Y., Choi, S.H., Park, J.E., Bang, J.K.
Plos One