CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.460.90
Functional Family Cyclic GMP-AMP synthase

Enzyme Information

2.7.7.86
Cyclic GMP-AMP synthase.
based on mapping to UniProt Q8C6L5
ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').
-!- Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.

UniProtKB Entries (1)

Q8C6L5
CGAS_MOUSE
Mus musculus
Cyclic GMP-AMP synthase

PDB Structure

PDB 4LEY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization.
Li, X., Shu, C., Yi, G., Chaton, C.T., Shelton, C.L., Diao, J., Zuo, X., Kao, C.C., Herr, A.B., Li, P.
Immunity